Overexpression of complement receptor type I (CR1, CD35) on erythrocytes in patients with hemoplasma infection
نویسندگان
چکیده
منابع مشابه
Hypoxia-induced expression of complement receptor type 1 (CR1, CD35) in human vascular endothelial cells.
Reoxygenation of hypoxic human umbilical vein endothelial cells (HUVECs) increases protein expression of the complement regulators CD46 and CD55. As the receptor for C3b is known to be present on injured bovine endothelial cells, we investigated whether hypoxia or inflammatory mediators induce complement receptor type 1 (CR1; CD35) expression on HUVECs. CR1 protein expression increased 3.7 +/- ...
متن کاملComplement receptor type 1 (CR1, CD35) is a potent inhibitor of B-cell functions in rheumatoid arthritis patients.
The involvement of B cells, complement activation and subsequent immune complex deposition has all been implicated in the pathogenesis of rheumatoid arthritis (RA). Although the reduced expression of complement receptor 1 (CR1, CD35) and 2 (CR2, CD21) on the B cells of RA patients has been known for a long time, their exact role in B-cell tolerance and autoimmunity is not yet fully understood. ...
متن کاملComplement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus
This study reports quantitative information on the concentration of complement receptor for C3b and C4b (CR1) on erythrocytes from normal individuals and patients with immune complex disease. The measurements were performed by an immunoradiometric assay using monoclonal antibodies against CR1. The antibody specificity was confirmed by immunoprecipitation of CR1 from extracts of surface-labeled ...
متن کاملCharacteristics of isolated erythrocyte complement receptor type one (CR1, C4b-C3b receptor) and CR1-specific antibodies.
Complement receptor type one (CR1) was isolated from detergent-solubilized human erythrocyte (E) membranes by modification of a previously described technique. The isolated CR, was labeled with 1251 and was shown to be bound by either C4bor CSb-coated sheep E (EAC14b or ECBb), but not by sheep E coated with either C3bi or C3d (EC3bi or EC3d). When analyzed by sodium dodecyl sulfate polyacrylami...
متن کاملQuantitative polymorphism of complement receptor type 1 (CR1) in patients undergoing haemodialysis.
BACKGROUND The level of complement receptor type 1 (CR1) on erythrocytes (E-CR1) is determined by the presence of high (H) or low (L) expression alleles. We investigated whether acquired loss of E-CR1 occurs in haemodialysis patients and, if so, which factors may contribute to acquired loss of E-CR1 in these patients. METHODS The E-CR1 level was determined in 195 Japanese haemodialysis patien...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 2010
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.2010.00240.x